�� 液体活检与ctDNA

*通过血液或其他体液中循环肿瘤DNA/细胞进行无创诊断的技术，包括ctDNA突变检测、cfDNA分析、CTC捕获等*

学术动态

1. Vision-based 深度学习 Analysis of Unordered Biomedical Tabular Datasets via Optimal Spatial Cartography

**来源**: arXiv preprint | **日期**: 2026-03-24 | **类型**: Preprint

Tabular data are central to biomedical research, from 液体活检 and bulk and single-cell 转录组学 to electronic health records and phenotypic profiling. Unlike images or sequences, however, tabular datasets la...

�� [阅读原文](http://arxiv.org/abs/2603.22675v1)

2. Bivariate deconvolution for 癌症 检测 after surgery

**来源**: arXiv preprint | **日期**: 2026-03-18 | **类型**: Preprint

检测 of minimal residual disease (MRD) in 癌症 patients after surgery can provide an early marker for disease recurrence and guide subsequent treatment decisions. Accurate and sensitive estimation of tumo...

�� [阅读原文](http://arxiv.org/abs/2603.17864v1)

3. Intelligent Nano-Fingerprinting: An Efficient and Precise Approach for 液体活检

**来源**: arXiv preprint | **日期**: 2026-01-17 | **类型**: Preprint

Biological matrices are rich in information related to life processes, serving as invaluable media for assessing an individual's overall physiological status and its dynamic fluctuations, as well as c...

�� [阅读原文](http://arxiv.org/abs/2601.11947v1)

4. Detecting Batch Heterogeneity via Likelihood Clustering

**来源**: arXiv preprint | **日期**: 2026-01-14 | **类型**: Preprint

Batch effects represent a major confounder in genomic diagnostics. In copy number 变异 (CNV) 检测 from NGS, many 算法s compare read depth between test 样本s and a reference 样本, assuming they are process-match...

�� [阅读原文](http://arxiv.org/abs/2601.09758v1)

5. 液体活检 reveals the immune status and protein profiles linked to CTC burden and 临床 outcomes in metastatic breast 癌症.

**来源**: J Exp Clin Cancer Res | **日期**: 2026 Apr 18 | **作者**: Kurma K, Bardol T, Mollevi C | **类型**: Journal Article

液体活检 reveals the immune status and protein profiles linked to CTC burden and 临床 outcomes in metastatic breast 癌症.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42001180/)

6. Developing 血液 extracellular vesicle protein 生物标志物s for hepatocellular carcinoma: mechanisms, methods, and translation.

**来源**: J Nanobiotechnology | **日期**: 2026 Apr 18 | **作者**: Zhuang Y, Zeng W, Long T | **类型**: Journal Article

Developing 血液 extracellular vesicle protein 生物标志物s for hepatocellular carcinoma: mechanisms, methods, and translation.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42001157/)

7. 液体活检 in modern medicine: advancing diagnostics from molecular insights to 临床 practice.

**来源**: Clin Transl Oncol | **日期**: 2026 Apr 18 | **作者**: Dhiman VK, Srivastava S, Kumari M | **类型**: Journal Article

液体活检 in modern medicine: advancing diagnostics from molecular insights to 临床 practice.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999549/)

8. Combined multi-omics and multi-spectral profiling of 血浆 细胞外囊泡 reveals 液体活检 生物标志物s for glioma 诊断.

**来源**: Cell Rep Med | **日期**: 2026 Apr 17 | **作者**: Robinson SD, Haile BT, Reily-Bell M | **类型**: Journal Article

Combined multi-omics and multi-spectral profiling of 血浆 细胞外囊泡 reveals 液体活检 生物标志物s for glioma 诊断.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999751/)

9. Identification and 验证 of 液体活检-based methylation 生物标志物s for germ cell 肿瘤 subtypes.

**来源**: Commun Med (Lond) | **日期**: 2026 Apr 17 | **作者**: Janssen FW, Gillis AJM, Gouswaart PB | **类型**: Journal Article

Identification and 验证 of 液体活检-based methylation 生物标志物s for germ cell 肿瘤 subtypes.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41998312/)

10. Long-Term Results of a Phase II 临床 Trial of Radiation Volume and Dose De-intensification Following Transoral Robotic Surgery and Neck Dissection for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma.

**来源**: Int J Radiat Oncol Biol Phys | **日期**: 2026 Apr 16 | **作者**: Lukens JN, Riina MD, Weinstein G | **类型**: Journal Article

Long-Term Results of a Phase II 临床 Trial of Radiation Volume and Dose De-intensification Following Transoral Robotic Surgery and Neck Dissection for Human Papillomavirus-Associated Oropharyngeal

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999781/)

11. Integrating PIK3CA Testing into 临床 Practice for Advanced HR+/HER2- Breast 癌症: An Expert Consensus.

**来源**: Breast | **日期**: 2026 Apr 10 | **作者**: De Angelis C, de Biase D, Gerratana L | **类型**: Journal Article

Integrating PIK3CA Testing into 临床 Practice for Advanced HR+/HER2- Breast 癌症: An Expert Consensus.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999684/)

12. Expanded subtype testing for circulating 肿瘤 HPV DNA reliably detects the presence of advanced-stage cervical 癌症.

**来源**: Gynecol Oncol | **日期**: 2026 Apr | **作者**: Rothnie K, Tristano E, Diaz-Rodriguez M | **类型**: Journal Article

Expanded subtype testing for circulating 肿瘤 HPV DNA reliably detects the presence of advanced-stage cervical 癌症.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42000375/)

13. Physical Limits of Proximal 肿瘤 检测 via MAGE-A 细胞外囊泡

**来源**: arXiv preprint | **日期**: 2025-12-29 | **类型**: Preprint

Early 癌症 检测 relies on invasive 组织 biopsies or liquid biopsies limited by 生物标志物 dilution. In contrast, tumour-derived 细胞外囊泡 (EVs) carrying 生物标志物s like melanoma-associated antigen-A (MAGE-A) are highly ...

�� [阅读原文](http://arxiv.org/abs/2512.23555v1)

__________________________________________________

�� 外泌体诊断

*利用外泌体（exosome）或细胞外囊泡（EV）携带的生物标志物进行疾病诊断，尤其在肿瘤早筛中应用广泛*

学术动态

1. Burn-associated metabolic dysfunction: could 细胞外囊泡 play a role?

**来源**: Clin Sci (Lond) | **日期**: 2026 May 13 | **作者**: Farahat M, DadashiZadeh G, Ricciuti Z | **类型**: Journal Article

Burn-associated metabolic dysfunction: could 细胞外囊泡 play a role?

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41994933/)

2. Differential expression analysis of 血清 exosome miRNAs in acral melanocytic 肿瘤.

**来源**: Pak J Pharm Sci | **日期**: 2026 Jun | **作者**: Zhu T, Wang J, Wang Y | **类型**: Journal Article

Differential expression analysis of 血清 exosome miRNAs in acral melanocytic 肿瘤.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42001282/)

3. Macrophage polarization as a therapeutic target in lung diseases: From pathogenesis to precision intervention.

**来源**: Int Immunopharmacol | **日期**: 2026 Apr 17 | **作者**: Kuang H, Chen Y, Yang X | **类型**: Journal Article

Macrophage polarization as a therapeutic target in lung diseases: From pathogenesis to precision intervention.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999690/)

4. Phosphorylated filamin-A at serine 1459 from 血浆-derived small 细胞外囊泡 as a promising 生物标志物 for high-risk adenoma and colorectal 癌症.

**来源**: Sci Rep | **日期**: 2026 Apr 17 | **作者**: Verathamjamras C, Chantaraamporn J, Sangwallek J | **类型**: Journal Article

Phosphorylated filamin-A at serine 1459 from 血浆-derived small 细胞外囊泡 as a promising 生物标志物 for high-risk adenoma and colorectal 癌症.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41998177/)

5. Roles of 细胞外囊泡 in the pathogenesis of chronic myeloid leukemia.

**来源**: J Physiol Biochem | **日期**: 2026 Apr 17 | **作者**: Hrdinova T, Kupcova Skalnikova H | **类型**: Journal Article

Roles of 细胞外囊泡 in the pathogenesis of chronic myeloid leukemia.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41995930/)

6. Translational advances of 外泌体 in neurodegeneration towards precision healthcare: From 生物标志物s to therapeutic frontiers.

**来源**: Biomed Pharmacother | **日期**: 2026 Apr 16 | **作者**: Sharma R, Song BS, Rane R | **类型**: Journal Article

Translational advances of 外泌体 in neurodegeneration towards precision healthcare: From 生物标志物s to therapeutic frontiers.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41997082/)

__________________________________________________

�� 伴随诊断（CDx）

*与特定药物绑定的诊断测试，用于筛选适合特定疗法的患者，提升精准用药效果*

学术动态

1. Molecular Profiling across 80,000 Patients with Lung 癌症.

**来源**: J Thorac Oncol | **日期**: 2026 Mar 26 | **作者**: Russo A, Javey M, Huang RSP | **类型**: Journal Article

Molecular Profiling across 80,000 Patients with Lung 癌症.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41903702/)

2. Barriers to 临床 implementation for novel therapies and 生物标志物 testing in the community practice oncology setting: A CLDN18.2 case study.

**来源**: Cancer Treat Res Commun | **日期**: 2026 Mar 23 | **作者**: Shreenivas A, Wright G, Vissers E | **类型**: Journal Article

Barriers to 临床 implementation for novel therapies and 生物标志物 testing in the community practice oncology setting: A CLDN18.2 case study.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41895224/)

3. Development and 验证 of a 肿瘤-derived CXCL1 qPCR 检测方法 to support patient selection for anti-CXCL1 therapeutics in bladder 癌症.

**来源**: Exp Mol Pathol | **日期**: 2026 Mar 16 | **作者**: Sakatani T, Tanaka S, Murakami K | **类型**: Journal Article

Development and 验证 of a 肿瘤-derived CXCL1 qPCR 检测方法 to support patient selection for anti-CXCL1 therapeutics in bladder 癌症.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41843975/)

4. HER-2 gene alterations as 生物标志物 in patients with metastatic colorectal 癌症 treated with FOLFIRI + cetuximab: findiNGS from the CAPRI-2 GOIM study.

**来源**: ESMO Gastrointest Oncol | **日期**: 2026 Mar | **作者**: Ciardiello D, Boscolo Bielo L, Napolitano S | **类型**: Journal Article

HER-2 gene alterations as 生物标志物 in patients with metastatic colorectal 癌症 treated with FOLFIRI + cetuximab: findiNGS from the CAPRI-2 GOIM study.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41994018/)

5. 伴随诊断s in 临床 Therapy: Current Applications and Future Directions.

**来源**: MedComm (2020) | **日期**: 2026 Mar | **作者**: Wu Y, Xue R, Luo X | **类型**: Journal Article

伴随诊断s in 临床 Therapy: Current Applications and Future Directions.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41777248/)

6. Bavachinin Suppresses Growth and Metastasis of Oral Squamous Cell Carcinoma through GSK-3β/β-Catenin Pathway: Potential for Synergistic Anti癌症 Therapy with Cisplatin.

**来源**: Biomed J | **日期**: 2026 Apr 7 | **作者**: Hsu PY, Leu YL, Chen CC | **类型**: Journal Article

Bavachinin Suppresses Growth and Metastasis of Oral Squamous Cell Carcinoma through GSK-3β/β-Catenin Pathway: Potential for Synergistic Anti癌症 Therapy with Cisplatin.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41956246/)

7. CALYPSO: Final Results of Savolitinib and Durvalumab Combination in Metastatic Papillary Renal 癌症.

**来源**: J Clin Oncol | **日期**: 2026 Apr 20 | **作者**: Jackson-Spence F, Larkin J, Patel P | **类型**: Journal Article

CALYPSO: Final Results of Savolitinib and Durvalumab Combination in Metastatic Papillary Renal 癌症.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41861260/)

8. Gemcitabine/nab-paclitaxel plus S-1 combination compared with gemcitabine/nab-paclitaxel in advanced pancreatic ductal adenocarcinoma: a retrospective study.

**来源**: Ther Adv Med Oncol | **日期**: 2026 | **作者**: Tseng KY, Hsu CY, Wu CH | **类型**: Journal Article

Gemcitabine/nab-paclitaxel plus S-1 combination compared with gemcitabine/nab-paclitaxel in advanced pancreatic ductal adenocarcinoma: a retrospective study.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41883866/)

__________________________________________________

�� 早筛早诊

*通过生物标志物、影像或液体活检技术实现癌症及其他疾病早期发现的检测产品*

学术动态

1. 早期检测 of Acute Myeloid Leukemia (AML) Using YOLOv12 深度学习 Model

**来源**: arXiv preprint | **日期**: 2026-04-17 | **类型**: Preprint

Acute Myeloid Leukemia (AML) is one of the most life-threatening type of 血液 癌症s, and its accurate classification is considered and remAIns a challenging task due to the visual similarity between vario...

�� [阅读原文](http://arxiv.org/abs/2604.16082v1)

2. FD-NL2SQL: Feedback-Driven 临床 NL2SQL that Improves with Use

**来源**: arXiv preprint | **日期**: 2026-04-17 | **类型**: Preprint

Clinicians exploring oncology trial repositories often need ad-hoc, multi-constrAInt queries over 生物标志物s, endpoints, interventions, and time, yet writing SQL requires schema expertise. We demo FD-NL2S...

�� [阅读原文](http://arxiv.org/abs/2604.15646v1)

3. Improved Multiscale Structural Mapping with Supervertex Vision Transformer for the 检测 of Alzheimer's Disease Neurodegeneration

**来源**: arXiv preprint | **日期**: 2026-04-16 | **类型**: Preprint

Alzheimer's disease (AD) confirmation often relies on positron emission tomography (PET) or cerebrospinal fluid (CSF) analysis, which are costly and invasive. Consequently, structural MRI 生物标志物s such ...

�� [阅读原文](http://arxiv.org/abs/2604.14837v1)

4. CoDaS: AI Co-Data-Scientist for 生物标志物 Discovery via Wearable Sensors

**来源**: arXiv preprint | **日期**: 2026-04-16 | **类型**: Preprint

Scientific discovery in digital health requires converting continuous physiological signals from wearable devices into 临床ly actionable 生物标志物s. We introduce CoDaS (AI Co-Data-Scientist), a multi-agent ...

�� [阅读原文](http://arxiv.org/abs/2604.14615v1)

5. An unsupervised decision-support framework for multivariate 生物标志物 analysis in athlete monitoring

**来源**: arXiv preprint | **日期**: 2026-04-16 | **类型**: Preprint

Purpose. Athlete monitoring is constrAIned by small cohorts, heterogeneous 生物标志物 scales, limited feasibility of repeated sampling, and the lack of reliable injury ground truth. These limitations reduc...

�� [阅读原文](http://arxiv.org/abs/2604.14534v1)

6. Data analysis of residents aged 40-59 in colorectal 癌症 screening in Pudong New Area, ShanghAI, 2013-2023.

**来源**: Sci Rep | **日期**: 2026 Apr 18 | **作者**: Li M, Wang Y, Zhang L | **类型**: Journal Article

Data analysis of residents aged 40-59 in colorectal 癌症 screening in Pudong New Area, ShanghAI, 2013-2023.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42000872/)

7. Qualitative System for Assessing Cytologic-Histologic Correlation in Non-Gynecologic Cytology 标本s.

**来源**: Acta Cytol | **日期**: 2026 Apr 18 | **作者**: Aly FZ, Shumate D, Khambaty SN | **类型**: Journal Article

Qualitative System for Assessing Cytologic-Histologic Correlation in Non-Gynecologic Cytology 标本s.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999620/)

8. False-positive iFOBT in colorectal 癌症 screening: Association with prescription drug use in The Malaysian Cohort.

**来源**: Cancer Epidemiol | **日期**: 2026 Apr 17 | **作者**: Abdullah N, Blin J, Khuzaimi AN | **类型**: Journal Article

False-positive iFOBT in colorectal 癌症 screening: Association with prescription drug use in The Malaysian Cohort.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999699/)

9. Towards interpretable AI in personalized medicine through a radiological-biological radiomics dictionary linking semantic Lung-RADS and imaging radiomics features.

**来源**: J Biomed Inform | **日期**: 2026 Apr 15 | **作者**: Jouzdani AF, Taeb S, Maghsudi M | **类型**: Journal Article

Towards interpretable AI in personalized medicine through a radiological-biological radiomics dictionary linking semantic Lung-RADS and imaging radiomics features.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41997262/)

10. Factors related to participation in colorectal 癌症 screening in a Southern European region: a prevalence survey.

**来源**: Eur J Public Health | **日期**: 2026 Apr 11 | **作者**: Martín-García P, Pichiule-Castañeda M, Domínguez-Berjón MF | **类型**: Journal Article

Factors related to participation in colorectal 癌症 screening in a Southern European region: a prevalence survey.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999638/)

11. P16/Ki67 dual stAIning versus cytology for identifying high-grade cervical intraepithelial neoplasia (CIN2+/CIN3+) in triage management of HR-HPV-positive women: a systematic review and meta-analysis.

**来源**: J Gynecol Oncol | **日期**: 2026 Apr 10 | **作者**: Zhou H, Dai Y, Zhang H | **类型**: Journal Article

P16/Ki67 dual stAIning versus cytology for identifying high-grade cervical intraepithelial neoplasia (CIN2+/CIN3+) in triage management of HR-HPV-positive women: a systematic review and meta-analysis.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41995269/)

12. Repeatability of automated body composition measurement on low dose chest CT in male subjects.

**来源**: PLoS One | **日期**: 2026 | **作者**: Bunk S, Bennink E, Sidorenkov G | **类型**: Journal Article

Repeatability of automated body composition measurement on low dose chest CT in male subjects.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41996421/)

13. Circulating 肿瘤 cell 检测 in 癌症 patients using in-flow 深度学习 holography.

**来源**: NPJ Biosens | **日期**: 2026 | **作者**: Mallery K, Bristow NR, Heller N | **类型**: Journal Article

Circulating 肿瘤 cell 检测 in 癌症 patients using in-flow 深度学习 holography.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41993926/)

__________________________________________________

�� POCT与居家检测

*即时检测（POCT）和居家自测产品，覆盖传染病、慢性病、生殖健康等多个领域*

学术动态

1. Real-Life Application of a 即时检测 Biosensor for Phenylalanine in Patients With Phenylketonuria.

**来源**: J Inherit Metab Dis | **日期**: 2026 May | **作者**: Gondrand C, Reischl-Hajiabadi AT, Bonedeau E | **类型**: Journal Article

Real-Life Application of a 即时检测 Biosensor for Phenylalanine in Patients With Phenylketonuria.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41989430/)

2. Intelligent POCT for ovarian 癌症: Dual-生物标志物 检测 combined with ROMA risk assessment using selenium nanoparticle.

**来源**: Anal Chim Acta | **日期**: 2026 Jun 22 | **作者**: Xie W, Wu J, Xie X | **类型**: Journal Article

Intelligent POCT for ovarian 癌症: Dual-生物标志物 检测 combined with ROMA risk assessment using selenium nanoparticle.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41997670/)

3. Dual-site PGM-based 即时检测 检测 of EGFR exon 19 deletion with an endogenous internal control.

**来源**: Biosens Bioelectron | **日期**: 2026 Apr 7 | **作者**: Jeon HW, Han H, Yang J | **类型**: Journal Article

Dual-site PGM-based 即时检测 检测 of EGFR exon 19 deletion with an endogenous internal control.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41990424/)

4. Simultaneous 即时检测 检测 and virulence typing of Helicobacter pylori using 多重 recombinase polymerase amplification combined with lateral flow strip.

**来源**: Eur J Clin Microbiol Infect Dis | **日期**: 2026 Apr 18 | **作者**: Song L, Yuan L, Ma Z | **类型**: Journal Article

Simultaneous 即时检测 检测 and virulence typing of Helicobacter pylori using 多重 recombinase polymerase amplification combined with lateral flow strip.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42000939/)

5. Diagnostic Accuracy, Satisfaction, and Acceptability of 即时检测 Testing for Syphilis, Hepatitis B, and Hepatitis C Infections among ThAI Adolescents and Young Adults with Sexual Risk Behaviors.

**来源**: Int J Infect Dis | **日期**: 2026 Apr 16 | **作者**: Chanthowong C, Mueangmo O, Saheng J | **类型**: Journal Article

Diagnostic Accuracy, Satisfaction, and Acceptability of 即时检测 Testing for Syphilis, Hepatitis B, and Hepatitis C Infections among ThAI Adolescents and Young Adults with Sexual Risk Behaviors.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999966/)

6. Cortisol as stress 生物标志物s: analytical perspective emphasis on matrix specific strategies, opportunities, and challenges.

**来源**: Clin Chim Acta | **日期**: 2026 Apr 16 | **作者**: Suryawanshi R, Sharma S | **类型**: Journal Article

Cortisol as stress 生物标志物s: analytical perspective emphasis on matrix specific strategies, opportunities, and challenges.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999929/)

7. Assessing the impact of an STI nurse on the delivery of STI/HIV services in an inner-city emergency department using a HIV/syphilis 即时检测 test during a syphilis outbreak in Alberta, Canada.

**来源**: Sex Transm Dis | **日期**: 2026 Apr 16 | **作者**: Gratrix J, Ives N, Egan C | **类型**: Journal Article

Assessing the impact of an STI nurse on the delivery of STI/HIV services in an inner-city emergency department using a HIV/syphilis 即时检测 test during a syphilis outbreak in Alberta, Canada.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41996301/)

8. Educating pharmacists to provide 即时检测 testing: Identifying the need for continuing education and trAIning within PharmD curricula.

**来源**: Curr Pharm Teach Learn | **日期**: 2026 Apr 15 | **作者**: Gangoo-Dookhan T, Colon CA, Dookhan K | **类型**: Journal Article

Educating pharmacists to provide 即时检测 testing: Identifying the need for continuing education and trAIning within PharmD curricula.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41990603/)

__________________________________________________

�� 蛋白质组与质谱诊断

*利用LC-MS/MS、质谱蛋白质组学技术进行临床生物标志物发现和诊断应用*

学术动态

1. Proteome-based identification and 验证 of NXPE3 in childhood acute lymphoblastic leukaemia.

**来源**: Pak J Pharm Sci | **日期**: 2026 Jun | **作者**: Tabassum N, Khurshid Y, Syed B | **类型**: Journal Article

Proteome-based identification and 验证 of NXPE3 in childhood acute lymphoblastic leukaemia.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42001290/)

2. Untargeted urinary 代谢组学 reveals metabolic alterations and severity 生物标志物s in cardiac surgery-associated acute kidney injury.

**来源**: Metabolomics | **日期**: 2026 Apr 18 | **作者**: Lee CC, Hsieh YJ, Chang CH | **类型**: Journal Article

Untargeted urinary 代谢组学 reveals metabolic alterations and severity 生物标志物s in cardiac surgery-associated acute kidney injury.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999450/)

3. A Critical Review on Analytical Techniques for Microplastics in Food Commodities.

**来源**: Crit Rev Anal Chem | **日期**: 2026 Apr 18 | **作者**: Rawat V, Sharma S, Kumar A | **类型**: Journal Article

A Critical Review on Analytical Techniques for Microplastics in Food Commodities.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999236/)

4. Insect-resistant soybean genotypes accumulate rutin and its O-methylated derivative narcissin, a more potent flavonol targeting Anticarsia gemmatalis digestive and detoxification enzymes and reducing larval survival.

**来源**: J Sci Food Agric | **日期**: 2026 Apr 18 | **作者**: de Assis JN, Pinheiro VJM, Varejão JOS | **类型**: Journal Article

Insect-resistant soybean genotypes accumulate rutin and its O-methylated derivative narcissin, a more potent flavonol targeting Anticarsia gemmatalis digestive and detoxification enzymes and reducing

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999131/)

5. Evaluating the Impact of Fentanyl Immuno检测方法 Cutoff Concentrations in Emergency Department, Maternal, and Neonatal Populations.

**来源**: J Anal Toxicol | **日期**: 2026 Apr 17 | **作者**: Harsha ML, Weaver K, Clarke WA | **类型**: Journal Article

Evaluating the Impact of Fentanyl Immuno检测方法 Cutoff Concentrations in Emergency Department, Maternal, and Neonatal Populations.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42001212/)

6. Identification of novel drug-specific PARP inhibitor resistance mechanisms in ovarian 癌症-implications for 临床 practice.

**来源**: Br J Cancer | **日期**: 2026 Apr 17 | **作者**: Macdonald CJ, McWhirter A, Vaidyanathan A | **类型**: Journal Article

Identification of novel drug-specific PARP inhibitor resistance mechanisms in ovarian 癌症-implications for 临床 practice.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41998207/)

7. Multi-media occurrence, bioaccumulation, and exposure assessment of PFAS across a Midwestern U.S. State.

**来源**: Environ Res | **日期**: 2026 Apr 16 | **作者**: Sepúlveda MS, Brown L, Capozzi SL | **类型**: Journal Article

Multi-media occurrence, bioaccumulation, and exposure assessment of PFAS across a Midwestern U.S. State.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42000107/)

8. Practical considerations for optimizing untargeted 代谢组学 with Synapt XS HRMS: A tutorial.

**来源**: J Chromatogr A | **日期**: 2026 Apr 14 | **作者**: Kaiser L, Riester O, Deigner HP | **类型**: Journal Article

Practical considerations for optimizing untargeted 代谢组学 with Synapt XS HRMS: A tutorial.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41999695/)

__________________________________________________

�� PCR与数字PCR

*聚合酶链式反应及其数字PCR分支，用于超灵敏基因突变检测和定量分析*

学术动态

1. HPV 检测 in Oropharyngeal 癌症: A Narrative Review of Diagnostic and Emerging Molecular Approaches.

**来源**: Diagnostics (Basel) | **日期**: 2026 Mar 27 | **作者**: López F, Bree R, Sreeram MP | **类型**: Journal Article

HPV 检测 in Oropharyngeal 癌症: A Narrative Review of Diagnostic and Emerging Molecular Approaches.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41975723/)

2. Development and 验证 of a crystal 数字PCR 检测方法 for duck Tembusu virus 检测 and vaccine monitoring.

**来源**: Poult Sci | **日期**: 2026 Mar 20 | **作者**: Liu H, Wang C, Wei X | **类型**: Journal Article

Development and 验证 of a crystal 数字PCR 检测方法 for duck Tembusu virus 检测 and vaccine monitoring.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41946073/)

3. Digital Uromonitor® outperforms quantitative polymerase chAIn reaction Uromonitor and cytology for non-muscle-invasive bladder 癌症 surveillance: results from the 'External 验证 of Uromonitor as a 生物标志物 for Optimization of NMIBC Management by the Club Urológico Español de Tratamiento Oncológico Group' (EVALUATION-CUETO) study.

**来源**: BJU Int | **日期**: 2026 Apr 6 | **作者**: Rubio-Briones J, Guerrero Ramos F, Mercadé Sánchez A | **类型**: Journal Article

Digital Uromonitor® outperforms quantitative polymerase chAIn reaction Uromonitor and cytology for non-muscle-invasive bladder 癌症 surveillance: results from the 'External 验证 of Uromonitor

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41941336/)

4. EXPRESS: Prevalence of the AIM exon 3 duplication 变异, a putative 生物标志物 associated with progression of kidney disease, in 1,000 cats.

**来源**: J Feline Med Surg | **日期**: 2026 Apr 17 | **作者**: Villarino NF, Hwang JK, Mealey KA | **类型**: Journal Article

EXPRESS: Prevalence of the AIM exon 3 duplication 变异, a putative 生物标志物 associated with progression of kidney disease, in 1,000 cats.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41994863/)

5. Prognostic value of combined 数字PCR and multiparametric flow cytometry monitoring MRD in non-transplant acute myeloid leukemia.

**来源**: J Hematop | **日期**: 2026 Apr 14 | **作者**: Ye S, Guo H, Xu J | **类型**: Journal Article

Prognostic value of combined 数字PCR and multiparametric flow cytometry monitoring MRD in non-transplant acute myeloid leukemia.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41979735/)

6. A Wireless Battery-Free Probe-Free Disposable Electrical-Digital-PCR Chip.

**来源**: IEEE Trans Biomed Circuits Syst | **日期**: 2026 Apr 10 | **作者**: Du S, Xuan Y, Shen Y | **类型**: Journal Article

A Wireless Battery-Free Probe-Free Disposable Electrical-Digital-PCR Chip.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41961575/)

7. Emerging 液体活检 markers in thyroid 癌症: from isolation technologies to 临床 translation.

**来源**: Front Endocrinol (Lausanne) | **日期**: 2026 | **作者**: Gao Y, Duan Q, Wei Y | **类型**: Journal Article

Emerging 液体活检 markers in thyroid 癌症: from isolation technologies to 临床 translation.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41993987/)

8. Non-invasive prenatal 诊断 of beta-thalassemia disease using 数字PCR.

**来源**: Front Med (Lausanne) | **日期**: 2026 | **作者**: Tangwerapornpong C, Traisrisilp K, Charoenkwan P | **类型**: Journal Article

Non-invasive prenatal 诊断 of beta-thalassemia disease using 数字PCR.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41982550/)

__________________________________________________

�� NGS与测序诊断

*基于二代测序（NGS）技术的肿瘤基因图谱、伴随诊断和全面基因组分析*

学术动态

1. Dental Panoramic Radiograph Analysis Using YOLO26 From Tooth 检测 to Disease 诊断

**来源**: arXiv preprint | **日期**: 2026-04-17 | **类型**: Preprint

Panoramic radiography is a fundamental diagnostic tool in dentistry, offering a comprehensive view of the entire dentition with minimal radiation exposure. However, manual interpretation is time-consu...

�� [阅读原文](http://arxiv.org/abs/2604.16231v1)

2. Dual-Modal Lung 癌症 AI: Interpretable Radiology and Microscopy with 临床 Risk Integration

**来源**: arXiv preprint | **日期**: 2026-04-17 | **类型**: Preprint

Lung 癌症 remAIns one of the leading causes of 癌症-related mortality worldwide. Conventional computed tomography (CT) imaging, while essential for 检测 and staging, has limitations in distinguishing benign...

�� [阅读原文](http://arxiv.org/abs/2604.16104v1)

3. AstroVLM: Expert Multi-agent Collaborative Reasoning for Astronomical Imaging Quality 诊断

**来源**: arXiv preprint | **日期**: 2026-04-17 | **类型**: Preprint

Vision Language Models (VLMs) have been applied to several specific domAIns and have shown strong problem-solving capabilities. However, astronomical imaging, a quite complex problem involving multidi...

�� [阅读原文](http://arxiv.org/abs/2604.16024v1)

4. PolarMAE: Efficient Fetal Ultrasound Pre-trAIning via Semantic Screening and Polar-Guided Masking

**来源**: arXiv preprint | **日期**: 2026-04-17 | **类型**: Preprint

Intelligent fetal ultrasound (US) interpretation is crucial for prenatal 诊断, but high annotation costs and operator-induced variance make unsupervised pre-trAIning a highly promising paradigm. However...

�� [阅读原文](http://arxiv.org/abs/2604.15893v1)

5. SegMix:Shuffle-based Feedback Learning for Semantic Segmentation of Pathology Images

**来源**: arXiv preprint | **日期**: 2026-04-17 | **类型**: Preprint

Segmentation is a critical task in computational pathology, as it identifies areas affected by disease or abnormal growth and is essential for 诊断 and treatment. However, acquiring high-quality pixel-l...

�� [阅读原文](http://arxiv.org/abs/2604.15777v1)

6. Molecular landscape of prostate 癌症s with clival metastases.

**来源**: Oncologist | **日期**: 2026 Mar 9 | **作者**: Likasitwatanakul P, Blinka SM, Zarka JG | **类型**: Journal Article

Molecular landscape of prostate 癌症s with clival metastases.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41782345/)

7. CRISPR-Cas12a/Cas13a in 癌症 molecular 诊断.

**来源**: Clin Chim Acta | **日期**: 2026 Mar 6 | **作者**: Lin J, Wang Y, Zeng B | **类型**: Journal Article

CRISPR-Cas12a/Cas13a in 癌症 molecular 诊断.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41796733/)

8. Investigating Genetic Risk to Oxaliplatin-Induced Sinusoidal Obstruction Syndrome in Colorectal 癌症 Through Routinely AvAIlable 二代测序 Data.

**来源**: Mod Pathol | **日期**: 2026 Mar 3 | **作者**: Zhang M, Wang P, Kong Y | **类型**: Journal Article

Investigating Genetic Risk to Oxaliplatin-Induced Sinusoidal Obstruction Syndrome in Colorectal 癌症 Through Routinely AvAIlable 二代测序 Data.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41786212/)

9. Integrative approaches in lung 癌症 诊断: bridging molecular 生物标志物s and AI driven imaging.

**来源**: Biomarkers | **日期**: 2026 Mar 19 | **作者**: Saha P, Yasmin A, Jha R | **类型**: Journal Article

Integrative approaches in lung 癌症 诊断: bridging molecular 生物标志物s and AI driven imaging.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41830914/)

10. Integrating liquid biopsies in non-small cell lung 癌症 诊断 and management: opportunities and challenges.

**来源**: Expert Rev Anticancer Ther | **日期**: 2026 Feb 15 | **作者**: Lim JU, Oya Y, Fu R | **类型**: Journal Article

Integrating liquid biopsies in non-small cell lung 癌症 诊断 and management: opportunities and challenges.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41656166/)

11. The Effects of BRCA1 and BRCA2 Promoter Methylation on Clinicopathological Characteristics and 临床 Outcomes in HGSOC.

**来源**: Cells | **日期**: 2026 Feb 1 | **作者**: Živić K, Boljević I, Nedeljković M | **类型**: Journal Article

The Effects of BRCA1 and BRCA2 Promoter Methylation on Clinicopathological Characteristics and 临床 Outcomes in HGSOC.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41677640/)

12. Costs and benefits of whole-exome, whole-transcriptome sequencing versus 50-gene  panels for genomic profiling in solid 肿瘤s.

**来源**: J Med Econ | **日期**: 2026 Dec | **作者**: Ortendahl JD, Carter GC, Zantema EM | **类型**: Journal Article

Costs and benefits of whole-exome, whole-transcriptome sequencing versus 50-gene  panels for genomic profiling in solid 肿瘤s.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41915379/)

13. Pathological features of BRCA-mutated breast 癌症 in Shenzhen, China: a single-center study.

**来源**: PeerJ | **日期**: 2026 | **作者**: Guan J, Lin S, Liu Y | **类型**: Journal Article

Pathological features of BRCA-mutated breast 癌症 in Shenzhen, China: a single-center study.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41800126/)

__________________________________________________

�� 免疫诊断

*利用抗原-抗体反应原理的诊断技术，包括ELISA、化学发光、免疫层析等*

学术动态

1. Genetic analysis and 临床 phenotype of pulmonary arterial hypertension in an Algerian population.

**来源**: Ann Saudi Med | **日期**: 2026 Mar-Apr | **作者**: Berkane AW, Yahiaoui R, Methia N | **类型**: Journal Article

Genetic analysis and 临床 phenotype of pulmonary arterial hypertension in an Algerian population.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42001268/)

2. 验证 of an optimized in-house enzyme-linked immunosorbent 检测方法 for enhanced 检测 of Trichinella spp. exposure in swine.

**来源**: Food Waterborne Parasitol | **日期**: 2026 Mar | **作者**: Lobanov VA, Konecsni KA, Scandrett WB | **类型**: Journal Article

验证 of an optimized in-house enzyme-linked immunosorbent 检测方法 for enhanced 检测 of Trichinella spp. exposure in swine.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41993137/)

3. Advances in ultrasensitive 检测 technologies for 血液-based 生物标志物s of Alzheimer's disease.

**来源**: J Mater Chem B | **日期**: 2026 Apr 17 | **作者**: Mou Y, Sun C, Deng K | **类型**: Journal Article

Advances in ultrasensitive 检测 technologies for 血液-based 生物标志物s of Alzheimer's disease.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41995126/)

4. D-dimer testing in cardiovascular disease: Laboratory and 临床 pitfalls.

**来源**: Kardiol Pol | **日期**: 2026 Apr 17 | **作者**: Sztefko K, Konieczyńska M, Bugajska J | **类型**: Journal Article

D-dimer testing in cardiovascular disease: Laboratory and 临床 pitfalls.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41994996/)

5. Dogs as sentinel hosts for sand-fly-borne infections in the Mediterranean Basin: a multinational serological survey.

**来源**: Parasit Vectors | **日期**: 2026 Apr 16 | **作者**: Oliva G, Bongiorno G, Ayhan N | **类型**: Journal Article

Dogs as sentinel hosts for sand-fly-borne infections in the Mediterranean Basin: a multinational serological survey.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/41992353/)

6. The downregulation of RAB10 by miR-574-5p alleviates the inflammatory response in neonatal respiratory distress syndrome.

**来源**: Exp Lung Res | **日期**: 2026 | **作者**: Ji Y, Zhou Y, Deng L | **类型**: Journal Article

The downregulation of RAB10 by miR-574-5p alleviates the inflammatory response in neonatal respiratory distress syndrome.

�� [阅读原文](https://pubmed.ncbi.nlm.nih.gov/42001430/)

__________________________________________________

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